Datasheet: Live Single Cell Functional Analysis with Beacon Discoveryâ„¢
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TCR Discovery Workflows on Beacon Platform

Functional, Fast, and Unbiased TCR Discovery with Bruker’s Optofluidic Platform

Cell Therapy /

Identifying antigen specific T-cell receptors (TCRs) is critical for advancing TCR-T therapies, vaccines, and infectious disease research. Yet, traditional peptide-MHC tetramer/dextramer sorting only tells part of the story – it relies on known epitopes and binding affinity, and often captures large numbers of non-functional T cells that fail to drive functional immune responses [1, 2]. […]

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Perfusion: The Beating Heart of Single-Cell Biology and Cancer Immunotherapy

Technology, Single Cell Functional Biology /

Single-cell biology has transformed our ability to uncover cellular diversity and dynamic behavior within complex tissues that are otherwise masked in population-level analyses. Yet, the precision of single-cell data critically depends on how cells are maintained and stimulated during experiments.  In static cultures, nutrient depletion and waste accumulation occur rapidly, altering cellular metabolism and gene

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Population Dynamics Workflow Overview

Introducing the Optoâ„¢ CLD with Population Dynamics Kit for Improved Stability Prediction

Announcement, Cell Line Development /

Since its introduction in 2017, the Beacon® platform has transformed how cell line development (CLD) teams reduce campaign risk and accelerate timelines. Today, over a third of CLD teams worldwide use the Beacon platform to streamline workflows and improve decision-making earlier in the process [1]. One of the greatest challenges in CLD is identifying clones

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Breaking New Ground in Functional Single-Cell Analysis: Meet the 2025 Beacon Discovery Grant Recipients

Single Cell Functional Biology /

We recently announced the winners of our 2025 Beacon Discoveryâ„¢ Global Grant Program. These selected researchers stood out for their innovative use of single-cell functional analysis to tackle complex biological questions in immunology, oncology, and cell therapy. Each project showcases how the Beacon Discovery optofluidic platform can reveal previously inaccessible functional insights at the single-cell

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Antibodies targeting the sporozoite pGlu-CSP site can prevent malaria

Enabling Antigen-Agnostic Antibody Discovery to Identify Novel Vaccine Epitopes Against Malaria

Antibody Discovery /

Malaria is a devastating mosquito-borne disease caused by Plasmodium parasites (Pf). The Pf sporozoite represents a bottleneck in the parasite’s life cycle and is an important target for malaria interventions. The most advanced anti-sporozoite strategies to date, including the World Health Organization-approved RTS,S/AS01 and R21/MM vaccines and monoclonal antibodies (mAbs) developed as clinical products, all

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Beacon Discoveryâ„¢ Unveiled at AACR 2025

Announcement /

At the recent American Association for Cancer Research (AACR) 2025 Annual Meeting held in Chicago last week, Bruker Cellular Analysis proudly unveiled the Beacon Discoveryâ„¢, a breakthrough benchtop platform designed to democratize live single-cell functional analysis. Buzzing with energy, the Bruker Cellular Analysis booth drew a crowd of passionate researchers, cutting-edge collaborators, and visionary innovators

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Beacon Discoveryâ„¢ Shines New Light on Functional Single-Cell Analysis

T Cell Profiling, Antibody Discovery, Cell Therapy /

Revolutionizing Functional Live Single-Cell Insights with the Beacon® Technology  Traditional single cell tools focus on static snapshots from one moment in a cell’s life, telling us what a cell expresses, what genes and proteins are turned on, and what surface markers are present. But they do not show how a cell behaves – they miss the

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Pushing the Boundaries in Cell Line Development: Webinar Recap

Cell Line Development /

This past February and March, Bruker Cellular Analysis, in partnership with BioProcess International, hosted a dynamic two-part webinar series – Pushing the Boundaries in Cell Line Development – spotlighting the capabilities of the Beacon® Optofluidic platform for cell line development (CLD). Now available on demand, these sessions offer a front-row view into how cutting-edge technology

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Efficiently Generating and Selecting Broadly Neutralizing Antibodies with Mosaic Nanoparticle Immunization and Multiplexed Screening

Antibody Discovery /

Therapeutic monoclonal antibodies (mAbs) have become less effective against SARS-CoV-2 infections as new variants arise due to point mutations in the spike protein that reduce antibody binding. To induce production of broadly neutralizing antibodies that target a conserved receptor-binding domain (RBD) region, protecting against multiple SARS-CoV-2 variants and zoonotic sarbecoviruses, researchers at the California Institute

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AI Needs More Than Sequences to Cure Cancer – It Needs Sequence Data Linked to Functional Outcomes

Cancer Signaling, Oncology, Cancer Immunology /

“If you want to advance human health and you’re not working towards AGI [Artificial General Intelligence]/ASI [Artificial Super Intelligence] right now the 2 most important things you can be building are enabling hardware and/or scientific data sets/reliable biological data that no one else can or will create. All the ‘AGI will solve cancer’ claims are

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