Navigating the field of antibody discovery requires a careful balance of innovative methodologies and advanced technologies. Traditional approaches often face limitations due to biases, or risk overlooking critical insights. To overcome these challenges, a recent study delved into harnessing the combined power of Bruker’s Beacon® system and PipeBio software for antigen-specific and cross-reactive antibody discovery. …
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Unlocking Insights in Antibody Discovery: An Integrated Approach with the Beacon® Platform and PipeBio
Exploring Species Diversity in Antibody Discovery on the Beacon® Optofluidic Platform
In the continually advancing field of biologics, it’s essential to search for new antibodies with distinct properties. The ability to screen primary B cells across diverse animal species broadens the diversity of recovered antibody sequences and increases the odds of finding the best antibody for any application across reagents, therapeutics, and basic health research. However, …
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Exploring a New Avenue in Vaccine Development: Targeting Conserved Epitopes with Broadly Neutralizing Antibodies
SARS-CoV-2’s ability to evolve quickly creates ongoing challenges for vaccine development. The spike protein, critical for the virus’s cell infection, undergoes rapid mutations, making antibodies less effective against new strains. Traditional vaccines, with their lengthy development and testing timelines, struggle to predict these evolutionary changes accurately, leading to a constant struggle to keep pace with …
Maximizing Monoclonal Antibody Success: Building a Foundation of B Cell Diversity
In the rapidly changing landscape of antibody discovery, researchers encounter significant challenges that necessitate inventive solutions. In a new on-demand webinar, we explore these obstacles and share an advanced approach to remain at the forefront of cutting-edge research capabilities. Current Challenges in Antibody Discovery Expanding Target Complexity: Traditional targets like GPCR and ion channels are …
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Published in Scientific Reports: Understanding Antibody-Secreting Cells: A Closer Look at Cellular Dynamics with Optofluidic Precision
The behavior of early-minted antibody-secreting cells (ASC) or plasmablasts post-infection or vaccination plays a pivotal role in the immune response. Traditionally, long-lived plasma cells (LLPC) from the bone marrow are regarded as non-dividing, while blood ASCs are thought to be proliferative. Traditional technologies that average bulk data or measure surface phenotype alone miss critical functional …
Navigating Challenges in B Cell Diversity by Leveraging Bruker’s Opto® Memory B Discovery Rabbit Sample Prep Kit on the Beacon® System
In antibody discovery, the screening of diverse antibody sequences is crucial to pinpoint the suitable antibodies for specific purposes. This challenge is particularly relevant in the context of rabbit antibodies, which are uniquely valuable reagents for basic research, diagnostics, and therapeutics development. Understanding Rabbit Antibodies Rabbits possess unique gene diversification strategies that result in antibodies …
Technology Spotlight: How the Beacon® Optofluidic System is Powering the Future of Research, Development, Manufacturing, and Clinical Testing
Bruker’s Beacon® systems provide function-first assays at single cell resolution on a microfluidic platform, utilizing the power of light-driven, Opto-Electro Positioning (OEP) to drive targeted, selective cell cloning into Nanopen® chambers capable of continual media perfusion and cell culture, whilst supporting a variety of assays and assessments across the chip architecture. These include: Live Cell …
Explore Cutting-Edge Antibody Discovery with Bruker Cellular Analysis at the Antibody Engineering & Therapeutics Conference
We’re excited to announce that from December 13-16, Bruker Cellular Analysis will be an exhibitor at this year’s Antibody Engineering & Therapeutics Conference in San Diego. This premier event is dedicated to showcasing the latest advancements in antibody engineering, design, and selection. With a focus on diverse topics such as Neurodegenerative Diseases, Tumor Microenvironment in …
Unveiling the Future of Protein and Antibody Research: The PEGS International Conference
The Protein & Antibody Engineering Summit (PEGS) International Conference, set to take place from November 14-16th at the Lisbon Congress Center in Lisbon, Portugal, is the largest protein & antibody engineering event in Europe, which has been described as “the best biologics technology meeting in Europe.” The team from Bruker Cellular Analysis will be at …
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Published in Antibody Therapeutics: Alpaca Single B Cell Interrogation and Heavy-Chain-Only Antibody Discovery on the Beacon® Platform
Researchers have used Bruker Cellular Analysis’ Optofluidic technology to establish the fastest high-resolution workflow for the discovery and engineering of VHH antibodies yet. Scientists developed a novel application leveraging Bruker’s optofluidic Beacon® platform to detect IgG2/3 antibodies from activated memory B cells derived from alpaca peripheral blood samples. B cells secreting PSMA-specific antibodies were recovered …
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