Optofluidic Chips

Cell Line
Development Kit

Streamline and expedite your cell line development process.

OVERVIEW
A Next Generation Solution That Streamlines and Expedites the Cell Line Development Process

Select high-titer clones and the best cells, significantly increasing your productivity when compared to traditional methods. Boost your throughput by up to 4 times, while reducing the development timeline by up to 50%, enabling quicker market entry. Recover clones of interest with over 99% monoclonality and enable efficient selection of clones with favorable product quality attributes within just 5 days of cloning. This translates to cost savings, higher success rates, and shorter timelines for scaling up the top-performing clones.

Product Guide

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Build a Kit
Customize your kit to examine various cell types and assay methods for Cell Line Development
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Application & Workflow
Select high-titer clones and the best cells, significantly increasing your productivity when compared to traditional methods
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Research & Data
Explore our application notes and publications to see how function-first analysis can be used to accelerate your research
Supported Instruments: Beacon®, Beacon Select™ for CLD
>99% Monoclonality Assurance

Get >99% monoclonality assurance with a single, automated round of cloning.

Export the Best Cells

Select top antibody clones by measuring growth, secretion, and productivity across cultures from 1000s of clones.

Selection Based on
Product Quality

Early identification of high-yield clones while minimizing late-stage failures.

Product Support
View our guides, manuals, and technical support resources.
Explore Cell Line
Development Applications
TECHNOLOGY
Cell Line Development Kit

Accelerate cell line development, boosting productivity by up to 4x

Compatible Instruments:

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In-Channel
  • Target viable, secreting cells in the channel while avoiding dying, non-secretors
  • Efficiently clone cells from recently transfected pools to access more genetic diversity​
In-Pen
  • Highly automated measurement of antibody productivity over several days
  • Perform Quality assays during the earliest stages of clone selection
CLD PRODUCTS
Build Your Kit

Our Cell Line Development Kit simplifies the process, enhances efficiency, and bolsters your success in the biopharmaceutical industry.

Cell Types  
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  • CHO Cells
Secreted Products  
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  • Traditional mAbs
  • Bispecific mAbs
  • Other biologics
Chip Types  
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OptoSelect® 1750b Chip (750-00018)
  • ~1,750 NanoPens per chip​
  • Large pen geometry allows for 
 culturing cells on chip
Assay Types  
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Opto® CLD 2.0

Traditional antibody therapeutic cell line development with CHO cells

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Quality Assays

Screen clones for Quality attributes, such as insoluble aggregate formation and % heterodimer for Bispefic mAbs

Other Biologics

Measure the productivity of clones for biologics that are not traditional mAbs (e.g., Vaccines and other proteins)

Assay Options  
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Human FC
  • SpotLight Human Fc Reagent (520-00024)
  • Opto® CLD Kit, Human Fc (750-08126)
  • Opto® CLD Kit, Human Fc + Kappa (750-08128)
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Human Kappa
  • SpotLight Human Kappa Reagent (520-08018)
  • Opto® CLD Kit, Human Kappa (750-08127)
  • Opto® CLD Kit, Human Fc + Kappa (750-08128)
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Human Lambda
  • SpotLight Human Lambda Reagent (520-08130)
Unprecedented Efficiency and Quality

Maximize Output, Minimize Time

>99% Monoclonality Assurance

Get >99% monoclonality assurance with a single, highly automated round of cloning.

Export the Best Cells

Select top antibody-producing clones by measuring growth, secretion, and productivity across cultures from 1000s of clones.

Assay for Aggregation

Confidently identify and select clones that are less likely to secrete antibodies that generate insoluble aggregates.

Selective Cell Cloning

Screen up to 100,000 cells in a single 5-day workflow. Enrich, identify, and clone only the cells that are viable and express your protein of interest.

Reduce Costs

Bypass less promising candidates and devote your resources to only the highest performing clones.

Automated

Screen thousands of cells in a highly automated process on the Beacon® system.

Build Your
Cell Line Development Kit
Resources
Research & Datasheets

Resource Type

Resource Type

Instrument

Instrument
Optofluidic Webinar
How to Speed Up the Cell Therapy Development Processes: Advancing CAR T Manufacturing Using Single Cell Analysis
How to Speed Up the Cell Therapy Development Processes: Advancing CAR T Manufacturing Using Single Cell Analysis
Speaker: Patrick Schmidt, PhD, Senior Research Associate, National Center for Tumor Diseases (NCT), German Center Research Center (DKFZ)
Optofluidic Webinar
Evaluation of Novel “Beacon” Cell Screening Technology for Improved and Expedited Cell Line Development
Evaluation of Novel “Beacon” Cell Screening Technology for Improved and Expedited Cell Line Development
Speaker: Rachel Ferguson, Associate Scientist III, Cell Line Development, Biogen
Optofluidic Webinar
Leveraging Innovative Technologies to Accelerate Biologics Development
Leveraging Innovative Technologies to Accelerate Biologics Development
Speaker: Joaquina Mascarenhas, PhD, at Thermo Fisher Scientific
Customer Spotlight
Catalent Biologics on Cell Line Development
E-Book
How to Get More Molecules to the Clinic Faster with Automated Cell Line Development
Datasheet
The Opto® Cell Line Development Workflow
Beacon® for Cell Line Development
Let’s Unleash the Full Potential of
Your Cell Line Development

Complete the form to connect with us and discover how the Beacon® technology can enhance your CLD programs.

Our expert team will be able to answer your questions, show you how the Beacon® system works, and share the most relevant datasheets & case studies for your research.