Optofluidic Chips

Antibody
Discovery Kit

Human / Mouse / Rabbit

A powerful automated solution for faster,
more precise Antibody Discovery

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OVERVIEW
Advanced Reagents and Chips that Streamline Monoclonal Antibody Discovery

Our best-in-class reagents and chips let you screen plasma cells or memory B cells and find valuable monoclonal antibodies within a week. Feeder-free activation and culture media ensure strong activation of memory B cells and longer secreting plasma cells for reliable results. Choose the right OptoSelect® chips to give you the screening throughput you need for simple or difficult targets. Simplify the recovery of antigen-specific antibody sequences for downstream analysis and development using our Unload and Sanger Prep kits. By using our products, you'll expedite your research and achieve more relevant and effective antibody discoveries in the process.

Product Guide

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Build a Kit
Customize your kit to examine various cell types and assay methods for antibody discovery
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Application & Workflow
Screen memory B cells or plasma cells and find valuable monoclonal antibodies within a week
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Research & Data
Explore our application notes and publications to see how function-first analysis can be used to accelerate your research
Supported Instruments:
Beacon®, Beacon Select™ for AbD, Beacon Quest™
Strong Activation

Feeder-free activation medium ensures strong activation of memory B cells and longer secreting plasma cells for reliable results.

Downstream Analysis

Simplify the recovery of antigen-specific antibody sequences for downstream analysis and development.

Faster Workflow

Expedite your research and achieve more relevant and effective antibody discoveries.

Product Support
View our guides, manuals, and technical support resources.
Technical Support
Explore Antibody Discovery
Workflows with Opto® B
View Application
TECHNOLOGY
Antibody Discovery Kit

A powerful automated solution for faster, more precise Antibody Discovery

Compatible Instruments:

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In-Channel
  • Simple to multiplex and/or perform sequential assays
  • Automated assay scoring available​
In-Pen
  • Requires significantly more optimization than in-channel assays
  • Manual assay scoring required​
  • Useful for low secretion rates and/or long assay readout times (e.g. cytotoxicity, reporter gene)
Species & Cell Type
Species and cell types supported for screening.
 
Memory B cells are isolated and activated in a fully chemically-defined, feeder-free medium to yield antibody secreting cells for Beacon® system screening.
 
Plasma cells are isolated and screened directly on the Beacon® system.
Chip Types
Choose a Chip type for your application based on cell type and assay needs.
Assay Beads
Beads used to carry out a multitude of Assay types.
Sequencing Kits
Used to amplify and sequence, and analyze differential gene expression profiles.
Library Prep Options
Used for library preparation for downstream sequencing.
ABD PRODUCTS
Build Your Kit
Species & Cell Type  
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Human
  • Memory B cells  (750-08323)
  • Plasma cells (750-02051)
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Mouse
  • Memory B cells  (750-08251)
  • Plasma cells  (750-02050)
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Rabbit
  • Memory B cells  (750-08251)
Chip Types  
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OptoSelect® 11k Chip (750-08090)
  • ~11,000 NanoPens per chip
  • Larger pen geometry for more robust in-pen assays
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OptoSelect® 20k Chip (750-00019)
  • ~20,000 NanoPens per chip
  • Larger pen geometry for more robust in-pen assays
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Other Species

Leverage the power and flexibility of single B cell screening to develop your own reagents and workflows for new species, targets, and assays such as cows, chickens, sheeps, goats, and camelids (alpaca, llama).

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Sequencing Kits  
Cell Opto® B Discovery cDNA Synthesis Kit  (750-02030)
OptoSeq® BCR OptoSeq® BCR Kit v2 (750-08238) Optional: Extended OptoSeq BCR Bead Unload Kit (750-08097)
OptoSeq® Barcoded BCR​ OptoSeq® Barcoded BCR Kit (750-01005) Optional: Extended OptoSeq BCR Bead Unload Kit (750-08097)
Library Prep Options  
Mouse (Wild Type) Opto® B Discovery Sanger Prep Kit, Mouse (750-01004)
OptoSeq® Barcoded BCR NGS Prep Kit, Mouse (750-02052)
Human Opto® B Discovery Sanger Prep Kit, Human (750-02041)
Rabbit Opto® B Discovery Sanger Prep Kit, Rabbit (750-08257)
Redefining Antibody Discovery

Unmatched Speed & Efficiency

Rapid Assays

Fast-track your B cell screening from months to hours.

Customizable

Mix and match our products or develop your own reagents and workflows for new species, targets, and assays.

Recovery

Unload the B cells you want, link their phenotype to genotypic sequence.

Re‐Expression

Directly incorporate BCR sequences into linear transcripts to transfect within days, not weeks.

Reduce Costs

Bypass less promising candidates and devote your resources to only the most promising ones.

Automated

Screen thousands of cells in automated process on the Beacon® system.

Build Your
Antibody Discovery Kit
Get in Touch
Resources
Research & Datasheets

Resource Type

Resource Type

Instrument

Instrument
App Note
Opto® Memory B Discovery Enables Multispecies Screening Capabilities
View Resource
Tech Note
Enabling Multispecies Screening Capabilities with Opto® Memory B Discovery
View Resource
Optofluidic Webinar
Building Broader B Cell Diversity for Better Monoclonal Antibody Discovery
Building Broader B Cell Diversity for Better Monoclonal Antibody Discovery
Speaker: Vincent Pai, Associate Director, Product Management, Bruker Cellular Analysis
Watch the Webinar
Optofluidic Webinar
Accelerating Antibody Discovery for Difficult Targets
Accelerating Antibody Discovery for Difficult Targets
Speaker: François Romagné, PhD, Professor, ImmunoTechnology, Aix Marseille University, Scientific Director, MI-mAbs
Watch the Webinar
App Note
Opto® Memory B Discovery Human Workflow
View Resource
App Note
Empowering Rapid and Robust Antibody Response: The Role of Next-Generation Antibody Discovery in Preparedness for Emerging Diseases and Endemic Threats
View Resource
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Beacon for Antibody Discovery
Let’s Unleash the Full Potential of
Your Antibody Discovery Research

Complete the form to connect with us and discover how the Beacon® technology can enhance your Antibody Discovery programs.

Our expert team will be able to answer your questions, show you how the Beacon® system works, and share the most relevant datasheets & case studies for your research.