Beacon® Discovery
Optofluidic System
Live Single Cells. Deepest Functional Insights.
Find the technology for your
research areas.
Why Functional Live Single-Cell Analysis Matters
See how live functional single-cell analysis is transforming biology by directly measuring cellular behavior, activity, and performance over time.
Beacon Discovery Links Function to Phenotype
Explore how the Beacon Discovery system connects function, phenotype, and multiomic measurements from live single cells to identify the cells that matter most.
Turn Functional Single-Cell Data into Insights
Design, automate, and analyze functional single-cell experiments with powerful software driving flexible workflows, intuitive visualizations, and AI-powered insights.
Vast Portfolio of Flexible, Function-First Assays
Leverage a vast portfolio of function-first assays to profile up to 60,000 B cells to generate rich, high-parameter datasets that power AI-driven antibody discovery.
Antibody Screening for Diverse and Challenging Targets
Screen diverse species, tissues, and B-cell types to discover high-value antibodies against challenging targets, including multi-transmembrane proteins, highly homologous targets, and low-immunogenic antigens.
Fast and Automated Workflow
Achieve the fastest path from sample to lead with one-day functional B cell screening, accelerated sequence recovery, and rapid antibody expression workflows for efficient lead selection.
Compress Cell Line Development Timelines
Reduce CLD timelines from months to days while identifying the most productive clones by cloning, screening, and selecting thousands of clones in parallel.
Thoroughly Characterize Clones with a Vast Assay Portfolio
Select high-performing clones faster with best-in-class assays for monoclonality, growth, productivity, quality, and stability, enabling confident clone selection and accelerated CLD timelines.
Confidently Submit IND Filings to Regulators
Gain superior monoclonality assurance with integrated imaging and in-process controls, delivering >99% monoclonality and a validated approach trusted by cell line development organizations.
Discover Effective CAR & TCR Sequences
Identify high-performing TCR and CAR candidates in days through single-cell functional screening that evaluates target interactions, cytotoxicity, cytokines, and surface markers.
Comprehensively Profile the Performance of Single T Cells
Profile single T-cell functionality with integrated assays for cytokines, cytotoxicity, and surface markers, reducing validation timelines and sample requirements for cell therapy development.
Sequence Recovered T Cells to Link Function to Genomics
Connect single-cell function to genomics by recovering and sequencing functionally characterized T cells, enabling integrated analysis of cellular behavior, gene expression, and TCR sequence profiles.
An Unmatched Live Single Cell Functional Solution
Experience the full potential of live single cell functional analysis with Beacon® Discovery. Powered by optofluidic technology, it enables researchers to explore multimodal and temporal cellular responses in real time, seamlessly linking functional data to sequencing from the same single cell for deeper scientific breakthroughs. This accessible, compact, and flexible system delivers unparalleled insights into immune profiling, cell therapy, and antibody and TCR/CAR discovery.
Key Product Features
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Compact, benchtop instrument
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Throughput: 1 chip, up to 20,000 single cells per run
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Five fluorescent channels (exchangeable cubes)
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4x bright field magnification
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Intuitive, customizable software
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Compatible with all OptoSelect® chips
Researcher Spotlights
See how top researchers use our technology to shape the next wave of scientific innovation.
“Having used the Beacon platform for years, we have seen firsthand how it transforms TCR discovery for cancer immunotherapy. Its automated workflows and novel multi-parameter temporal analysis allow precise characterization of tumor antigen-specific T cells, accelerating the identification of potent therapeutic candidates from patient tumor-infiltrating lymphocytes (TILs). With the new Beacon Discovery platform, this powerful technology is now within reach for many more individual and core labs in academia and industry.”
BEACON DISCOVERY
Bring Live Single-Cell Functional Analysis to Your Lab
Complete the form to connect with us and discover how the Beacon Discovery system can enhance your research adventure.
Our expert team will be able to answer your questions, show you how the Beacon Discovery system works, and share the most relevant datasheets & case studies for your research.
Bruker’s frequently asked questions
The Beacon Discovery is an accessible, compact, benchtop instrument powered by optofluidic technology and designed to run 1 chip at a time.
