Opto B Discovery on the Beacon® platform revolutionizes antibody discovery (AbD) with its function-first, high-throughput single B cell screening, maximizing the success of your antibody campaigns.
By conducting multiple functional assays, including antigen specificity, affinity, cross-reactivity, cell-based functions, and blocking assays, on tens of thousands of cells in a single run, the Beacon platform delivers the highest level of characterization for each single cell.
The Opto B Discovery workflows on the Beacon platform provides an unparalleled, efficient, and reliable solution for antibody discovery, ensuring your success with both easy and challenging targets.
Revolutionizing Antibody Discovery
of Antibody Discovery with the Beacon Platform
Conduct up to 16 functional assays, including antigen specificity, affinity, cross-reactivity, ligand blocking, internalization, and cell-based function, on up to 60,000 B cells per run, generating up to 1 million data points and maximizing antibody characterization. Empower artificial intelligence (AI)-based antibody discovery by leveraging the rich, high-parameter data generated by the Beacon platform to train data-hungry AI models.
Optimize your antibody discovery process with the innovative Opto® B Discovery Affinity Assay. This cutting-edge tool allows researchers to rapidly rank antibody hits based on relative affinity, enhancing the selection of top candidates early in the discovery process.
Screen antibodies across diverse species (human, mouse, rabbit, alpaca, and more), organ types (spleen, bone marrow, lymph nodes, and peripheral blood) and cell types (plasma and memory B cells), resulting in diverse antibody hits with even the most challenging targets, including multi-transmembrane proteins, targets with high host homology, and low immunogenicity antigens.
Diverse Host Species
for Challenging Targets
Empower screening with small-volume samples and customizable assays suitable for therapeutic antibodies in any disease area. Optofluidics are ideal for small or precious human samples (as few as a single patient draw) and enable broad applications, ranging from vaccine development for infectious diseases, discovering autoantibodies responsible for autoimmune disorders, and identifying novel antibodies against tumor-associated antigens (TAAs) for oncology.
Opto Memory B Discovery Human Workflow
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Streamline antibody discovery by minimizing screening time and expenses. B cells can be screened for functionality in just one day, allowing the advancement of only the most promising candidates. The single B cell BCR recovery & library prep kits convert exported hits into antibody sequences within a week. Additionally, one-step cDNA cloning facilitates the rapid expression of recovered antibodies, promoting efficient lead characterization and selection.
Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein
Hear the story behind the publication from Dr. James Crowe, Vanderbilt University: How Art Inspired the Development of the Covid-19 Vaccine
At the core of the Beacon system is a combination of optics and nanofluidics called optofluidics. The OptoSelect® chips replace typical well plates. Each OptoSelect chip contains thousands of NanoPen® chambers, which replace wells on a microplate. This is where cells are selectively placed, cultured and characterized using a myriad of proprietary Beacon Platform assays.
- Comprehensive assays
1 million or more multi-modal data points for specificity, cross-reactivity, affinity, blocking, and function - Broad species compatibility
Total end-to-end solutions for mouse, rabbit, human, and alpaca, with a rapid path to onboard others (e.g. rat, chicken) - High-throughput screening
Up to 60,000 single cells screened for every assay you choose - Automated sequence recovery
Recover 192 to 1000s of paired heavy and light chains - Rapid single-day workflow
Understand the life of single cells through functional cellular analysis with the Beacon Platform.
Your Antibody Discovery Research
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