Our Advanced Antibody Discovery Platform is Now More Accessible
The same amazing technology scaled to meet your needs and budget
Beacon Select™ Optofluidic System for Antibody Discovery
The Beacon Select™ system is a 2-chip single-cell optofluidic instrument for antibody discovery (AbD) that cuts the time and cost to get the best antibody lead candidates by using Opto® B Discovery workflows.
- Find antibody sequences against rare targets where others can’t
- Tailor your lead candidate discovery to any target and function, including functional blockers and the high-affinity molecules
- Discover up to 10-fold more hits, access 50-fold greater sequence diversity, and reduce costs by 20-fold in a matter of days, not weeks
Fast, powerful workflow for antibody discovery
Reduce AbD timelines and downstream costs by screening B cells for function in a single day and taking only the best candidates forward.
Screen tens of thousands of B cells in parallel and select the best B cells to recover sequences from in hours, not months.
"The main reason why we employ the Beacon® system here at Abveris is to enable deep characterization of single B cells in multiple sequential assays. Its design allows for precise control over the movement of cells, leaving you with the ultimate flexibility in assay design and, as a result, higher screening resolution."
“The throughput of two Beacon systems, coupled with our genetic immunization technology, has increased the probability of campaign success by delivering 10-fold more lead candidates against difficult targets like GPCRs.”
AbD workflows find winners quickly and flexibly
Functionally screen tens of thousands of B cells on a chip simultaneously.
The Beacon Select for AbD system enables game changing process improvements for simultaneous incubation and screening of thousands of clones on a chip
Customize your assays to find your best antibodies
Assays for soluble and membrane-bound targets can be customized and run sequentially and/or in multiplex with Opto B Discovery on Beacon Select. Leverage multiple fluorophores, detection molecules, and your available antigens to screen B cells in minutes to hours, not months.
At the core of the Beacon Select system is a combination of optics and nanofluidics called optofluidics
The OptoSelect® chips replace typical well plates. Each OptoSelect chip contains thousands of NanoPen® chambers, which are like wells on a microplate. This is where cells are deposited, where they grow and where they are characterized using a myriad of proprietary Bruker Cellular Analysis assays.
Beacon Workflow Modules
Screening thousands of cells is an automated process on the Beacon system with our four workflow modules: Import, Culture, Assay and Export. These modules can be adapted, interchanged and deployed with a variety of single-cell assays to address specific applications and a variety of cell types.
Our software automatically identifies single cells and directs them into NanoPen chambers all at once. Chips are loaded with cells in less than 30 minutes.
As cells proliferate, nutrients diffuse in, waste diffuses out, and software images the chip continuously to count cells and calculate growth rate.
Test individual cells immediately and repeatedly in our NanoPen® chambers, instead of culturing for weeks to reach a minimum number of cells for assay.
Choose your cells of interest. Light patterns move them into position for export to a well plate.
Recover lead molecules, not just sequences
Re-express >1,000 antibodies in 1 week without gene synthesis and cloning.
The Opto BCR Rapid Re-expression kit converts antibody sequences into molecules in just 1 week for plate-based confirmation assays. Amplified cDNA is cloned into expression constructs in one step, enabling expression of >1,000 antibodies for rapid functional confirmation.