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See how top researchers are using our technology to predict durable responses and unlock pre-clinical meaning.

Cancer Immunology
Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer.
Axelrod ML, Nixon ML, Gonzalez-Ericsson PI, Bergman RE, Pilkinton MA, McDonnell WJ, Sanchez V, Opalenik S, Loi S, Zhou J, Mackay S, Rexer BN, Abramson VG, Jansen VM, Mallal SA, Donaldson J, Tolaney SM, Krop I, Garrido-Castro AC, Marotti JD, Shee K, Miller TW, Sanders M, Mayer IA, Salgado R, and Balko JM.. Clinical Cancer Research. 2020.
Cancer Immunology
Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice.
Huang J, Zhou J, Ghinnagow R, Seki T, Iketani S, Soulard D, Paczkowski P, Tsuji Y, Mackay S, Cruz LJ, Trottein F, and Tsuji M.. Frontiers in Immunology. 2020.
Inflammation & Neurology, Vaccines & Infectious Disease
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19.
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat. BMC Neurology. 2020.
Cellular and Regenerative Medicine
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity.
Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan K-L, and Kaufman DS.. Cell Stem Cell. 2020.
Cancer Immunology
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line.
Su Y, Ko ME, Cheng H, Zhu R, Xue M, Wang J, Lee JW, Frankiw L, Xu A, Wong S, Robert L, Takata K, Yuan D, Lu Y, Huang S, Ribas A, Levine R, Nolan GP, Wei W, Plevritis SK, Li G, Baltimore D, and Heath JR.. Nature Communications. May 11, 2020.
Cellular and Regenerative Medicine
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression.
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martinez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim Y-M, Heisterkamp N, Abdel-Azim H, and Ahmed N.. Leukemia. 2020.
Cellular and Regenerative Medicine
Advanced Cell Mapping Visualizations for Single Cell Functional Proteomics Enabling Patient Stratification.
Bowman N, Liu D, Paczkowski P, Chen J, Rossi J, Mackay S, Bot A, and Zhou J.. Proteomics. 2020.
Cell Line Development
Methods for Estimating the Probability of Clonality in Cell Line Development
Chen C, Le K, Le H, Daris K, Soice N, Stevens J, Goudar CT. Biotechnology Journal. 2020.
Antibody Discovery
Rapid single B cell antibody discovery using nanopens and structured light
Winters A, McFadden K, Bergen J, Landas J, Berry KA, Gonzalez A, Salimi-Moosavi H, Murawsky CM, Tagari P, King CT. MAbs. 2019.
Cellular and Regenerative Medicine
Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.
Li D, Li N, Zhang YF, Fu H, Feng M, Schneider D, Su L, Wu X, Zhou J, Mackay S, Kramer J, Duan Z, Yang H, Kolluri A, Hummer AM, Torres MB, Zhu H, Hall MD, Luo X, Chen J, Wang Q, Abate-Daga D, Dropublic B, Hewitt SM, Orentas RJ, Greten TF, and Ho M.. Gastroenterology. 2020.
Cancer Immunology
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist.
Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavare R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM, Comin-Anduix B, Charych D, and Ribas A.. Nature Communications. 2020.
Cancer Immunology
SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma.
Chen Y-P, Kim HJ, Wu H, Price-Troska T, Villasboas JC, Jalali S, Feldman AL, Novak AJ, Yang, Z-Z, and Ansell SM.. Blood Cancer Journal. 2019.
Cellular and Regenerative Medicine
Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma.
Schmidts A, Ormhoj M, Choi BD, Taylor AO, Bouffard AA, Scarfo I, Larson RC, Frigault MJ, Gallagher K, Castano AP, Riley LS, Cabral ML, Boroughs AC, Velasco Cardenas RM-H, Schamel W, Zhou J, Mackay S, Tai Y-T, Anderson KC, Maus MV.. Blood Advances. 2019.
Cancer Immunology
Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs.
Xiao Y, Liu C, Blatchley MR, Kim D, Zhou J, Xu M, Gerecht S, and Fan R.. Advanced Biosystems. 2019.
Antibody Discovery
Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring
Jorgolli M, Nevill T, Winters A, Chen I, Chong S, Lin F, Mock M, Chen C, Le K, Tan C, Jess P, Xu H, Hamburger A, Stevens J, Munro T, Wu M, Tagari P, Miranda LP. Biotechnology and Bioengineering. May 21, 2019.
Cancer Immunology, Cellular and Regenerative Medicine
Single-Cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies.
Liu D, Paczkowski P, Mackay S, Ng Colin, and Zhou J.. Biomarkers for Immunotherapy of Cancer - Springer. 2019.
Cellular and Regenerative Medicine
Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL.
Rossi J, Paczkowski P, Shen Y, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, and Bot A. Blood. 2018.
Cellular and Regenerative Medicine
A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication.
Zhou J, Bethune MT, Malkova N, Sutherland AM, Begonya CA, Su Y, Baltimore D, Ribas A, and Heath JR. PLoS One 13 (1). 2018.
Inflammation & Neurology
Enhanced TLR2 Responses in Multiple Sclerosis.
Fujiwara M, Anstadt EJ, Flynn B, Morse K, Ng C, Paczkowski P, Zhou J, Mackay S, Wasko N, Nichols F, Clark RB. Clinical and Experimental Immunology. 2018.
Cell Line Development
A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology
Le K, Tan C, Gupta S, Guhan T, Barkhordarian H, Lull J, Stevens J, Munro T. Biotechnology Progress. 2018.
Cell Line Development
Light-activated cell identification and sorting (LACIS) for selection of edited clones on a nanofluidic device
Mocciaro A, Roth TL, Bennett HM, Soumillon M, Shah A, Hiatt J, Chapman K, Marson A, Lavieu G. Communications Biology. May 3rd, 2018.
Cellular and Regenerative Medicine
Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia.
Fraietta JA, Lacey SF, Orlando E, Pruteanu J, Gohil M, Wang Y, Boesteanu A, O'Connor R, Ambrose DE, Hwang WT, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Parakandi H, Gupta M, Pequignot E, Johnson FB, Kulikovskaya I, Liu L, Lundh SM, Xu J, Davis MM, Young RM, Levine BL, Siegel DL, Huang A, Wherry EJ, Zhou J, Paczkowski P, Mackay S, Brogdon J, Bitter H, Porter DL, June CH, and Melenhorst JJ. Blood 130 (Suppl. 1) 3181. 2017.
Cellular and Regenerative Medicine
Single-Cell Multiplexed Cytokine Profiling of CD19 CAR-T Cells Reveals a Diverse Landscape of Polyfunctional Antigen-Specific Response.
Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim S, and Zhou J. Journal for ImmunoTherapy of Cancer. 5:85. 2017.
Cellular and Regenerative Medicine
Polyfunctional Anti-CD19 CAR T Cells Determined by Single-Cell Multiplex Proteomics Associated with Clinical Activity in Patients with Advanced Non-Hodgkin’s Lymphoma.
Rossi J, Paczkowski P, Shen Y, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, and Bot A. Proc. AACR Annual Meeting 177 (13 Suppl.) 2990. 2017.
Oncology
Single-Cell Analysis Resolves the Cell State Transition and Signaling Dynamics Associated with Melanoma Drug-Induced Resistance.
Su Y, Wei W, Robert L, Xue M, Tsoi J, Garcia-Diaz A, Homet Moreno B, Kim J, Ng R, Lee JW, Koya RC, Comin-Anduix B, Graeber TG, Ribas A, and Heath JR. Proc. Natl. Acad. Sci.. 2017.