Publications - Bruker Cellular Analysis

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Publications & Presentations

See how top researchers are using our technology to predict durable responses and unlock pre-clinical meaning.

T Cell Profiling

Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture

Zenga, J, Musaddiq A, Frei A, Foeckler J, Kuehn R, Villareal Espinosa O, Bruening J, Massey B, Wong S, Shreenivas A, Shulka M, Kasprzak J, Sun Y, Shaheduzzaman MD, Chen F, Kearl T, Himburg H. Translational Oncology. 2024.

Antibody Discovery

Rapid isolation of pan-neutralizing antibodies against Omicron variants from convalescent individuals infected with SARS-CoV-2

Yu P, Ran J, Yang R, Zhu H, Lu S, Wu Y, Zhao T, Xiong T. Frontiers in Immunology. 2024.

Antibody Discovery, Vaccines & Infectious Disease

Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture

Nguyen DC, Saney C, Hentenaar IT, Cabrera-Mora M, Capric V, Woodruff MC, Andrews J, Lonial S, Sanz I, Eun-Hyung Lee F. Scientific Reports. 2024.

T Cell Profiling

Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy

Colina AS, Shah V, Shah RK, Kozlik T, Dash RK, Terhune S, Zamora AE. Frontiers in Molecular Medicine. 2024.

Oncology

Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma

Griesinger AM, Riemondy K, Eswaran N, Donson AM, Willard N, Prince EW, Paine SML, Bowes G, Rheaume J, Chapman RJ, Ramage J, Jackson A, Grundy RG, Foreman NK, Ritzmann TA. iScience. 2023.

Cancer Immunology

NK cells propagate T cell immunity following in situ tumor vaccination

Jin WJ, Jagodinsky JC, Vera JM, Clark PA, Zuleger CL, Erbe AK, Ong IM, Le T, Tetreault K, Berg T, Rakhmilevich AL, Kim K, Newton MA, Albertini MR, Sondel PM, Morris ZS. Cell Reports. 2023.

Vaccines & Infectious Disease

HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity

Migueles SA, Nettere DM, Gavil NV, Wang LT, Toulmin SA, Kelly EP, Ward AJ, Lin S, Thompson SA, Peterson BA, Abdeen CS, Sclafani CR, Pryal PF, Leach BG, Ludwig AK, Rogan DC, Przygonska PA, Cattani A, Imamichi H, Sachs A, Cafri G, Huang NN, A, Liang CJ, Hallahan CW, Kambach DM, Han EX, Coupet T, Chen J, Moir SL, Chun TW, Coates EE, Ledgerwood J, Schmidt J, Taillandier-Coindard M, Michaux J, Pak H, Bassani-Sternberg M, Frahm N, McElrath MJ, Connors M. Science. 2023.

Inflammation & Neurology, Vaccines & Infectious Disease

Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection

First NJ, Parrish KM, Martínez-Pérez A, González-Fernández A, Bharrhan S, Woolard M, McLachlan JB, Scott RS, Wang J, Gestal1 MC. Cell Reports. 2023.

Cellular and Regenerative Medicine

AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival

Mehra V, Agliardi G, Dias Alves Pinto J, Shafat MS, Garai AC, Green L, Hotblack A, Arce Vargas F, Peggs KS, van der Waart AB, Dolstra H, Pule MA, Roddie C. Journal for Immunotherapy of Cancer. 2023.

Cancer Immunology

Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy

Shah RK, Cygan E, Kozlik T, Colina A, Zamora AE. Frontiers in Immunology. 2023.

Cellular and Regenerative Medicine

Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy

Nowicki TS, Peters CW, Quiros C, Kidd CK, Kawakami M, Klomhaus AM, Baselga-Carretero I, Kaplan-Lefko P, Macabali MH, Perez Garcilazo I, Beata Berent-Maoz B, Comin-Anduix B, Antoni Ribas A. Cancer Immunology Research. 2023.

Cellular and Regenerative Medicine

Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression

Jiang W, Gu G, Zhang Y, Song Y, Shi M, Wang G, Li H, Tao T, Qin J, Li X, Jia H, Jiao F, Xu W, Huang X. Pharmacological Research. 2023.

Cellular and Regenerative Medicine

Hypoxia-responsive CAR-T cells exhibit reduced exhaustion and enhanced efficacy in solid tumors

Zhu X, Chen J, Li W, Xu Y, Shan J, Hong J, Zhao Y, Xu H, Ma J, Shen J, Qian C. Cancer Research. 2023.

Cellular and Regenerative Medicine

Exploiting the CD200-CD200R Immune Checkpoint Axis in Multiple Myeloma to Enhance CAR-T Therapy

Tang Y, Liu W, Kadu S, Johnson O, Hasanali ZS, Kelly AR, Shestov AA, Greenblat E, Holmes M, Wang LP, Shih N, O'Connor RS, Garfall A, Allman D, Vogl DT, Cohen AD, June CH, Sheppard NC. Blood. 2023.

Antibody Discovery

Alpaca single B cell interrogation and heavy-chain-only antibody discovery on an optofluidic platform

Shapiro MB, Boucher J, Brousseau A, Dehkharghani A, Gabriel J, Kamat V, Patil K, Gao F, Walker J, Kelly R, Souders CA. Antibody Therapeutics. 2023.

Cancer Immunology

Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer

Naulaerts S, Datsi A, Borras DM, Antoranz Martinez A, Messiaen J, Vanmeerbeek I, Sprooten J, Laureano RS, Govaerts J, Panovska D, Derweduwe M, Sabel MC, Rapp M, Ni W, Mackay S, Van Herck Y, Gelens L, Venken T, More S, Bechter O, Bergers G, Liston A, De Vleeschouwer S, Van Den Eynde B, Lambrechts D, Verfaillie M, Bosisio F, Tejpar S, Borst J, Sorg RV, De Smet F, Garg A. Science Translational Medicine. 2023.

Vaccines & Infectious Disease

Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence

Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Ollmann Saphire E. Cell Reports. 2023.

Cellular and Regenerative Medicine

The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer

Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, de Val N, Ashworth D, Ni W, Zhou J, Mackay S, Hewitt SM, Cachau R, Ho M. Nature Communications. 2023.

Cancer Immunology

Dual Axl/MerTK inhibitorINCB081776 creates a proinflammatory tumorimmune microenvironment and enhancesanti-PDL1 efficacy in head and neck cancer.

Kourtney L. Kostecki, Mari Iida, Anne L. Wiley, Stanley Kimani, Bridget Mehall, Kaitlin Tetreault, Roxana Alexandridis, Menggang Yu, Seungpyo Hong, Ravi Salgia, Justine Y. Bruce, Raymond B. Birge, Paul M. Harari, Deric L. Wheeler. Head & Neck. 2023;45(5):1255‐1271. doi:10.1002/hed.27340.

Cancer Immunology

Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity

Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Chandrashekhar P, Koh AY. Science Immunology. 2023.

Cancer Immunology, Vaccines & Infectious Disease

Clinical trials of self-replicating RNA-based cancer vaccines

Morse MA, Crosby EJ, Force J, Osada T, Hobeika AC, Hartman ZC, Berglund P, Smith J, Lyerly HK. Cancer Gene Therapy. 2023.

Cancer Immunology

Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models

Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon II JE, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Science Translational Medicine. 2023.

Cellular and Regenerative Medicine

Synapse-tuned CARs enhance immune cell anti-tumor activity

Chockley PJ, Ibanez-Vega J, Krenciute G, Talbot LJ, Gottschalk S. Nature Biotechnology. 2023.

Cancer Immunology

Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity

Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y. Science Advances. 2023.

Oncology

Multiparameter Single-Cell Characterization of Ovarian Intratumor Heterogeneity

Beaumont KG, Andreou C, Ellis E, Sebra R. Methods in Molecular Biology. 2022.

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