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1 - 25 of 200 Publications
Cancer Immunology, Cellular and Regenerative Medicine
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
Shanley M, Daher M, Dou J, Li S, Basar R, Rafei H, Dede M, Gumin J, Pantaleรณn Garcรญa J, Nunez Cortes AK, He S, Jones CM, Acharya S, Fowlkes NW, Xiong D, Singh S, Shaim H, Hicks SC, Liu B, Jain A, Zaman MF, Miao Q, Li Y, Uprety N, Liu E, Muniz-Feliciano L, Deyter GM, Mohanty V, Zhang P, Evans SE, Shpall EJ, Lang FF, Chen K, Rezvani K. Cancer Cell. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells
Pascual-Pasto G, McIntyre B, Giudice AM, Alikarami F, Morrissey A, Matlaga S, Hofmann TJ, Burgueรฑo V, Harvey K, Martinez D, Shah AC, Foster JB, Pogoriler J, Eagle RC, Carcaboso AM, Shields CL, Leahey AM, Bosse KR. Clinical Cancer Research. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma
Pascual-Pasto G, McIntyre B, Hines MG, Giudice AM, Garcia-Gerique L, Hoffmann J, Mishra P, Matlaga S, Lombardi S, Shraim R, Schรผrch PM, Yarmarkovich M, Hofmann TJ, Alikarami F, Martinez D, Tsang M, Gil-de-Gรณmez L, Spear TT, Bernt KM, Wolpaw AJ, Dimitrov DS, Li W, Bosse KR. Nature Communications. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies
Dong Z, Budde LE, Oh E, Szymura S, Anderson A, Del Real M, Cha S, Forman SJ, Kwak LW, Wang X. Blood Advances. 2024.
Immunology
Stimulation-induced cytokine polyfunctionality as a dynamic concept
Portmann K, Linder A, Eyer K. eLife. 2024.
Oncology
Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma
Lai TJ, Sun L, Li K, Prins TJ, Treger J, Li T, Sun MZ, Nathanson DA, Liau LM, Lai A, Prins RM, Everson RG. Cancer Research Communications. 2024.
Immunology
Generation of nanobodies from transgenic โ€˜LamaMiceโ€™ lacking an endogenous immunoglobulin repertoire
Eden T, Schaffrath AZ, Wesolowski J, Stรคhler T, Tode N, Richter N, Schรคfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall CM, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt AJ, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor CG, Hartlepp KF, Schleer H, Fรผner J, Tomas NM, Haag F, Rissiek B, Mann AM, Menzel S, Koch-Nolte F. Nature Communications. 2024.
Vaccines & Infectious Disease
Novel Bacteroides Vulgatus strain protects against gluteninduced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept study
Tran T, Senger S, Baldassarre M, Brosnan RA, Cristofori F, Crocco M, De Santis S, Elli L, Faherty CS, Francavilla R, Goodchild-Michelman I, Kenyon VA, Leonard MM, Lima RS, Malerba F, Montuori M, Morelli A, Norsa L, Passaro T, Piemontese P, Reed JC, Sansotta N, Valitutti F, Zomorrodi AR, Fasano A. Pediatric Research. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition
Andreu-Saumell I, Rodriguez-Garcia A, Mรผhlgrabner V, Gimenez-Alejandre M, Marzal B, Castellsaguรฉ J, Brasรณ-Maristany F, Calderon H, Angelats L, Colell S, Nuding M, Soria-Castellano M, Barbao P, Prat A, Urbano-Ispizua A, Huppa JB, Guedan S. Nature Communications. 2024.
Cancer Immunology
CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4
Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B. JCI. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
Marin D, Li Y, Basar R, Rafei H, Daher M, Dou J, Mohanty V, Dede M, Nieto Y, Uprety N, Acharya S, Liu E, Wilson J, Banerjee P, Macapinlac HA, Ganesh C, Thall PF, Bassett R, Ammari M, Rao S, Cao K, Shanley M, Kaplan M, Hosing C, Kebriaei P, Nastoupil LJ, Flowers CR, Moseley SM, Lin P, Ang S, Popat UR, Qazilbash MH, Champlin RE, Chen K, Shpall EJ, Rezvani K. Nature Medicine. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells
Kathari YK, Ahmad H, Kallen ME, Koka R, Omili D, Iraguha T, Clement J, Pham L, Khalid M, Fan X, Gebru E, Lesho P, Park E, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Badros A, Yared JA, Dahiya S, Hardy NM, Kocoglu H, Luetkens T, Rapoport AP, Atanackovic D. Haematologica. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Treatment of secondary CNS lymphoma using CD19โ€‘targeted chimeric antigen receptor (CAR) T cells
Kline K, Luetkens T, Koka R, Kallen ME, Chen W, Ahmad H, Omili D, Iraguha T, Gebru E, Fan X, Miller A, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Yared JA, Hardy NM, Rapoport AP, Dahiya S, Atanackovic D. Cancer Immunology, Immunotherapy. 2024.
Oncology
Differential Regulation of the STING Pathway in Human Papillomavirusโ€“Positive and -Negative Head and Neck Cancers
Saulters EL, Kennedy PT, Carter RJ, Alsufyani A, Jones TM, Woolley JF, Dahal LN. Cancer Research Communications. 2024.
Oncology
Inorganic Nanoparticles Change Cancer-Cell-Derived Extracellular Vesicle Secretion Levels and Cargo Composition, Resulting in Secondary Biological Effects
Buttiens K, Maksoudian C, Perez Gilabert I, Rios Luci C, Manshian BB, Soenen SJ. ACS Applied Materials & Interfaces. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity
Landoni E, Woodcock MG, Barragan G, Casirati G, Cinella V, Stucchi S, Flick LM, Withers TA, Hudson H, Casorati G, Dellabona P, Genovese P, Savoldo B, Metelitsa LS, Dotti G. Nature Communications. 2024; doi: 10.1038/s41467-023-44310-y.
Oncology
Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma
Lai, T; Sun, L; Li, K; Prins, T; Treger, J; Li, T; Sun, M; Nathanson, D; Liau, L; Lai, A; Prins, R; Everson, R. Cancer Research Communication. 2024.
Antibody Discovery
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, Huynh T, Browne W, Tubati A, Haney MS, Douglas VC, Louine M, Cree BAC, Hauser SL, Seeley W, Baranzini SE, Wells JA, Spudich S, Farhadian S, Ramachandran PS, Gillum L, Hales CM, Zikherman J, Anderson MS, Yazdany J, Smith B, Nath A, Suh G, Flanagan EP, Green AJ, Green R, Gelfand JM, DeRisi JL, Pleasure SJ, Wilson MR. Science Translational Medicine. 2024.
Antibody Discovery
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Lawrence TW, Cooper A J.R., Farrell B, Draper S, Higgins MK. Cell. 2024.
Cell Line Development
Combined approach of selective and accelerated cloning for microfluidic chip-based system increases clone specific productivity
Desmurget C, Frentzel J, Strembitska A, Sobkowiak K, Perilleux A, Souquet J, Borth N, Douet J. Biotechnology Journal. 2024.
Cellular and Regenerative Medicine
Pretreatment with IL-15 and IL-18 rescues natural killer cells from granzyme B-mediated apoptosis after cryopreservation
Berjis A, Muthumani D, Aguilar OA, Pomp O, Johnson O, Finck AV, Engel NW, Chen L, Plachta N, Scholler J, Lanier LL, June CH, Sheppard NC. Nature Communications. 2024.
Cancer Immunology, Oncology
Single-mitosis dissection of acute and chronic DNA mutagenesis and repair
Ginno PA, Borgers H, Ernst C, Schneider A, Behm M, Aitken SJ, Taylor MS, Odom DT. Nature Genetics. 2024.
Cancer Immunology, T Cell Profiling
DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma
Kirk AM, Crawford JS, Chou CH, Guy C, Pandey K, Kozlik T, Shah RK, Chung S, Nguyen P, Zhang X, Wang J, Bell M, Mettelman RC, Allen EK, Pogorelyy MV, Kim H, Minervina AA, Awad W, Bajracharya R, White T, Long Jr. D, Gordon B, Morrison M, Glazer ES, Murphy AJ, Jiang Y, Fitzpatrick EA, Yarchoan M, Sethupathy P, Croft NP, Purcell AW, Federico SM, Stewart E, Gottschalk S, Zamora AE, DeRenzo C, Strome SE, Thomas PG. Cell Reports Medicine. 2024.
T Cell Profiling
Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
Zenga, J, Musaddiq A, Frei A, Foeckler J, Kuehn R, Villareal Espinosa O, Bruening J, Massey B, Wong S, Shreenivas A, Shulka M, Kasprzak J, Sun Y, Shaheduzzaman MD, Chen F, Kearl T, Himburg H. Translational Oncology. 2024.
Antibody Discovery
Rapid isolation of pan-neutralizing antibodies against Omicron variants from convalescent individuals infected with SARS-CoV-2
Yu P, Ran J, Yang R, Zhu H, Lu S, Wu Y, Zhao T, Xiong T. Frontiers in Immunology. 2024.