Every year, head and neck cancers (HNC) claim thousands of lives, with over 54,000 cases diagnosed annually in the United States alone, resulting in approximately 11,000 fatalities.1 HNCs are particularly difficult to treat—about one in three patients will not survive five years after diagnosis, despite a range of treatment options including surgery, radiation, chemotherapy, and […]
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Published in Head & Neck: Cytokine Profiling Reveals How Novel Kinase Inhibitor Slows Tumor Cell Growth by Altering Tumor Microenvironment
Published in Science Translational Medicine: Single-Cell Secretome Reveals Functional Profiles of Immune Cells in Hard-To-Treat Cancers
Cancer has long been one of the most challenging diseases to treat as traditional treatments, like chemotherapy and radiation, can be harsh on the body and are not always successful. However, recent advancements in the field of immunotherapy have improved anti-cancer treatments; one of the more promising immunotherapy approaches being Immune Checkpoint Blockade (ICB) therapy. […]
Revolutionizing Immunotherapy Research and Development With the New Opto® T Cell Profiling Workflow
Polyfunctional T cells, which produce multiple cytokines, are considered to be the most potent anti-tumor effector T cells. To find polyfunctional T cells in a heterogeneous sample, researchers must be able to characterize functional cytokine secretion and cytotoxicity at the single-cell level. However, most existing methods evaluate samples in bulk and are destructive endpoint assays, […]
Exploring the Phenome Across Discovery and Development: Single-Cell Research Featured at AACR 2023
We attended this year’s AACR meeting and wanted to thank everyone for such an incredible turnout and experience as we introduced Bruker Cellular Analysis to many of you for the first time. We had a great time speaking with so many amazing researchers that are enthusiastic about our technology, and loved to see all of […]
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