Optimize your antibody discovery process with the innovative Opto® B Discovery Affinity Assay. This cutting-edge tool allows researchers to rapidly rank antibody hits based on relative affinity, enhancing the selection of top candidates early in the discovery process.
Leveraging the Beacon® Optofluidic System, this assay enables the identification of hundreds to thousands of antigen-specific hits with unparalleled precision. By efficiently ranking these hits, the Opto® B Discovery Affinity Assay transforms downstream lead optimization and antibody engineering, yielding more antibodies with desirable affinity characteristics. It also provides validated, large-scale data for in silico antibody optimization.
The Opto ® B Discovery Affinity Assay transforms downstream lead optimization and antibody engineering by yielding more antibodies with desirable affinity characteristics, while providing validated data at scale for in silico antibody optimization.
of Antibody with Affinity Assay
The Opto® B Discovery Affinity Assay offers a fast and powerful workflow for antibody discovery, powered by the Beacon® platform. Traditional methods often require weeks of re-expressing and characterizing antibodies, which can lead to undesirable affinity outcomes. However, with this assay, researchers can generate Beacon Affinity Scores in real-time, providing early insights into binding strength and allowing for quick, confident decisions on candidate prioritization.
Once antibody-secreting cells are isolated on the Beacon® system, researchers can perform a customizable on-chip assay using species-specific IgG capture beads and fluorescently labeled antigens. Within minutes, the system identifies antibody hits, quantifies the captured antibodies, and calculates fluorescence-based relative Beacon Affinity Scores.
Affinity Rankings
For professionals in biopharma, CRO/CDMO, academia, and biotechnology, the Opto® B Discovery Affinity Assay is a revolutionary tool. It enables rapid, high-throughput ranking of antibody hits, expediting discovery while improving downstream success rates. The assay has been validated against industry-standard techniques such as biolayer interferometry (BLI), ensuring reliable and accurate affinity rankings at an unprecedented scale.
AI-driven antibody design models need large-scale and quantitative binding affinity data to evolve discovered antibody hits toward more desirable biophysical and biochemical molecules. The Beacon platform with Antibody Affinity Assay excels at generating this crucial functional data at scale for every recovered sequence, bridging the gap for data-hungry AI models and enhancing lead optimization efforts.
Go beyond traditional soluble antigen-binding assay and prioritize functional assays first to deliver rich, high parameter data and more relevant antibody insights
Read more about how to transform your antibody research
with the Opto® B Discovery Affinity Assay.
Your Antibody Discovery Research
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