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The tumor microenvironment (TME) promotes tumor growth and metastasis while suppressing anti-cancer immune responses.
This has proven to be a barrier to adoptive cell therapy. Oncolytic adenoviruses (OAds) can disrupt the TME, thereby restoring and improving immune cell function. However, delivering OAds to solid tumors is challenging.
Researchers from Baylor College of Medicine took a creative approach to this problem by studying how mesenchymal stromal cells (MSCs) can be used to directly deliver two engineered anti-cancer adenoviruses to tumor sites.
Together with CAR-T cell therapy, this approach disrupted the TME, suppressed tumor growth, and encouraged T cell activity.
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