With this kit, you can simultaneously investigate the functional aspects of T cells as they interact with target cells, gaining valuable insights into the diverse mechanisms that regulate cytokine secretion using customizable cytokine assays and cell surface markers. The kit enables the characterization of polyfunctionality, cytotoxicity, genotype, and gene expression, providing a complete understanding of T cell behavior. Furthermore, you can sort, select, and load cells, making it possible to isolate desired phenotypes from heterogeneous T cell samples.
Our cytotoxicity assay, helps visualize distinct killing behaviors in your T cell samples. Once the functional characterization is complete, cells of interest can be exported for expansion or further study, facilitating the linkage of their behavior to genotype.
Customizable cytokine assays reveal T cell interactions and diverse cytokine secretion mechanisms.
Visualize T cell killing behaviors using caspase-3 activation and identify the cells that matter.
Recover and sequence your cells to link phenotype and gene expression in a single workflow.
Applications
Thoroughly profile single T cells and link their phenotypic and functional data to their genotypes
Compatible Instruments:
This T cell profiling kit allows you to explore T cell behavior by investigating cytokine secretion, surface markers, polyfunctionality, cytotoxicity, genotype, and gene expression, facilitating cell isolation, visualization of killing behaviors, and subsequent export for expansion or further study, connecting cell behavior to genotype.
Can be used to perform function-forward screening to identify TCR sequences
Can be used to screen CAR libraries (DKFZ webinar), validate targets, optimize CAR manufacturing
As described in the MCW webinar, the Antigen Presenting Bead kit can be used to screen targets, and to then activate and expand T Cells
- ~3,550 NanoPens per chip
- Large pen geometry allows for loading up to 3 multiplexed beads in addition to up to 2 cell types
Used to amplify TCR alpha and beta chains, and prepare them for next-generation sequencing.
Used to amplify and sequence cDNA and analyze differential gene expression profiles.
Rapid, Single-Cell Multiomic T Cell Profiling
T Cell Profiling Kit
Resource Type
Instrument
Your T Cell Profiling Research
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