Medical College of Wisconsin on T Cell Characterization
Identifying the Biological Properties of Car T Cells That Favor Tumor Killing Using the Lighting™ Single Cell System
Listen in on Dr. Anthony Zamora’s talk from CAR-TCR Summit 2021. Dr. Zamora covers topics, including:
Identifying how modifications in CAR T cell manufacturing can improve in-vivo persistence and clinical efficacy by determining the mechanisms and specific features of T cell biology that drive these therapeutic responses.
Sharing two striking observations made when assessing antitumor activity of single CAR T cells against single tumor targets:
- Observing the great deal of heterogeneity in the cytotoxic kinetics – something often missed when performing similar assays on bulk populations of cells, and how this may be exploited to increase therapeutic efficacy.
- Describing how differences in CAR T cell manufacturing (e.g., using IL-2 or IL-7/15 during activation/expansion) results in disparate functional profiles
— Dr. Anthony Zamora, Assistant Professor at Medical College of Wisconsin