The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer
Dual Axl/MerTK inhibitorINCB081776 creates a proinflammatory tumorimmune microenvironment and enhancesanti-PDL1 efficacy in head and neck cancer.
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors
Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses