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1 - 30 of 146 Publications
Cancer Immunology, T Cell Profiling
DNAJB1-PRKACA fusion neoantigens elicit rare endogenous T cell responses that potentiate cell therapy for fibrolamellar carcinoma
Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Villareal Espinosa O, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA. Cell Reports Medicine. 2024.
T Cell Profiling
Tumor-specific T cells in head and neck cancer have rescuable functionality and can be identified through single-cell co-culture
Zenga J, Awan M, Frei A, Foeckler J, Kuehn R, Villareal Espinosa O, Bruening J, Massey B, Wong S, Shreenivas A, Shukla M, Kasprzak J, Sun Y, Shaheduzzaman M, Chen F, Kearl T, Himburg HA. Translational Oncology. 2024.
Antibody Discovery
Rapid isolation of pan-neutralizing antibodies against Omicron variants from convalescent individuals infected with SARS-CoV-2
Yu P, Ran J, Yang R, Zhu H, Lu S, Wu Y, Zhao T, Xiong T. Frontiers in Immunology. 2024.
Antibody Discovery, Vaccines & Infectious Disease
Majority of human circulating IgG plasmablasts stop blasting in a cell-free pro-survival culture
Nguyen DC, Saney C, Hentenaar IT, Cabrera-Mora M, Capric V, Woodruff MC, Andrews J, Lonial S, Sanz I, Eun-Hyung Lee F. Scientific Reports. 2024.
Current advances in experimental and computational approaches to enhance CAR T cell manufacturing protocols and improve clinical efficacy
Colina AS, Shah V, Shah RK, Kozlik T, Dash RK, Terhune S, Zamora AE. Frontiers in Molecular Medicine. 2024.
Vaccines & Infectious Disease
HIV vaccines induce CD8+ T cells with low antigen receptor sensitivity
Migueles SA, Nettere DM, Gavil NV, Wang LT, Toulmin SA, Kelly EP, Ward AJ, Lin S, Thompson SA, Peterson BA, Abdeen CS, Sclafani CR, Pryal PF, Leach BG, Ludwig AK, Rogan DC, Przygonska PA, Cattani A, Imamichi H, Sachs A, Cafri G, Huang NN, A, Liang CJ, Hallahan CW, Kambach DM, Han EX, Coupet T, Chen J, Moir SL, Chun TW, Coates EE, Ledgerwood J, Schmidt J, Taillandier-Coindard M, Michaux J, Pak H, Bassani-Sternberg M, Frahm N, McElrath MJ, Connors M. Science. 2023.
Inflammation & Neurology, Vaccines & Infectious Disease
Bordetella spp. block eosinophil recruitment to suppress the generation of early mucosal protection
First NJ, Parrish KM, Martínez-Pérez A, González-Fernández A, Bharrhan S, Woolard M, McLachlan JB, Scott RS, Wang J, Gestal1 MC. Cell Reports. 2023.
Cellular and Regenerative Medicine
AKT inhibition generates potent polyfunctional clinical grade AUTO1 CAR T-cells, enhancing function and survival
Mehra V, Agliardi G, Dias Alves Pinto J, Shafat MS, Garai AC, Green L, Hotblack A, Arce Vargas F, Peggs KS, van der Waart AB, Dolstra H, Pule MA, Roddie C. Journal for Immunotherapy of Cancer. 2023.
Cancer Immunology
Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy
Shah RK, Cygan E, Kozlik T, Colina A, Zamora AE. Frontiers in Immunology. 2023.
Cellular and Regenerative Medicine
Infusion Product TNFα, Th2, and STAT3 Activities Are Associated with Clinical Responses to Transgenic T-cell Receptor Cell Therapy
Nowicki TS, Peters CW, Quiros C, Kidd CK, Kawakami M, Klomhaus AM, Baselga-Carretero I, Kaplan-Lefko P, Macabali MH, Perez Garcilazo I, Beata Berent-Maoz B, Comin-Anduix B, Antoni Ribas A. Cancer Immunology Research. 2023.
Cellular and Regenerative Medicine
Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression
Jiang W, Gu G, Zhang Y, Song Y, Shi M, Wang G, Li H, Tao T, Qin J, Li X, Jia H, Jiao F, Xu W, Huang X. Pharmacological Research. 2023.
Cellular and Regenerative Medicine
Hypoxia-responsive CAR-T cells exhibit reduced exhaustion and enhanced efficacy in solid tumors
Zhu X, Chen J, Li W, Xu Y, Shan J, Hong J, Zhao Y, Xu H, Ma J, Shen J, Qian C. Cancer Research. 2023.
Cellular and Regenerative Medicine
Exploiting the CD200-CD200R Immune Checkpoint Axis in Multiple Myeloma to Enhance CAR-T Therapy
Tang Y, Liu W, Kadu S, Johnson O, Hasanali ZS, Kelly AR, Shestov AA, Greenblat E, Holmes M, Wang LP, Shih N, O'Connor RS, Garfall A, Allman D, Vogl DT, Cohen AD, June CH, Sheppard NC. Blood. 2023.
Antibody Discovery
Alpaca single B cell interrogation and heavy-chain-only antibody discovery on an optofluidic platform
Shapiro MB, Boucher J, Brousseau A, Dehkharghani A, Gabriel J, Kamat V, Patil K, Gao F, Walker J, Kelly R, Souders CA. Antibody Therapeutics. 2023.
Cancer Immunology
Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer
Naulaerts S, Datsi A, Borras DM, Antoranz Martinez A, Messiaen J, Vanmeerbeek I, Sprooten J, Laureano RS, Govaerts J, Panovska D, Derweduwe M, Sabel MC, Rapp M, Ni W, Mackay S, Van Herck Y, Gelens L, Venken T, More S, Bechter O, Bergers G, Liston A, De Vleeschouwer S, Van Den Eynde B, Lambrechts D, Verfaillie M, Bosisio F, Tejpar S, Borst J, Sorg RV, De Smet F, Garg A. Science Translational Medicine. 2023.
Vaccines & Infectious Disease
Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence
Hastie KM, Yu X, Ana-Sosa-Batiz F, Zyla DS, Harkins SS, Hariharan C, Wasserman H, Zandonatti MA, Miller R, Maule E, Kim K, Valentine KM, Shresta S, Ollmann Saphire E. Cell Reports. 2023.
Cellular and Regenerative Medicine
The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer
Li N, Quan A, Li D, Pan J, Ren H, Hoeltzel G, de Val N, Ashworth D, Ni W, Zhou J, Mackay S, Hewitt SM, Cachau R, Ho M. Nature Communications. 2023.
Cancer Immunology
Dual Axl/MerTK inhibitorINCB081776 creates a proinflammatory tumorimmune microenvironment and enhancesanti-PDL1 efficacy in head and neck cancer.
Kourtney L. Kostecki, Mari Iida, Anne L. Wiley, Stanley Kimani, Bridget Mehall, Kaitlin Tetreault, Roxana Alexandridis, Menggang Yu, Seungpyo Hong, Ravi Salgia, Justine Y. Bruce, Raymond B. Birge, Paul M. Harari, Deric L. Wheeler. Head & Neck. 2023;45(5):1255‐1271. doi:10.1002/hed.27340.
Cancer Immunology
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity
Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Chandrashekhar P, Koh AY. Science Immunology. 2023.
Cancer Immunology, Vaccines & Infectious Disease
Clinical trials of self-replicating RNA-based cancer vaccines
Morse MA, Crosby EJ, Force J, Osada T, Hobeika AC, Hartman ZC, Berglund P, Smith J, Lyerly HK. Cancer Gene Therapy. 2023.
Cancer Immunology
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models
Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon II JE, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V. Science Translational Medicine. 2023.
Cellular and Regenerative Medicine
Synapse-tuned CARs enhance immune cell anti-tumor activity
Chockley PJ, Ibanez-Vega J, Krenciute G, Talbot LJ, Gottschalk S. Nature Biotechnology. 2023.
Cancer Immunology
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y. Science Advances. 2023.
Oncology
Multiparameter Single-Cell Characterization of Ovarian Intratumor Heterogeneity
Beaumont KG, Andreou C, Ellis E, Sebra R. Methods in Molecular Biology. 2022.
Cancer Immunology
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
Crist M, Yaniv B, Palackdharry S, Lehn MA, Medvedovic M, Stone T, Gulati S, Karivedu V, Borchers M, Fuhrman B, Crago A, Curry J, Martinez-Outschoorn U, Takiar V, Wise-Draper TM. Journal for ImmunoTherapy of Cancer. 2022.
Cancer Immunology
First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors
Davis EJ, Martin-Liberal J, Kristeleit R, Cho DC, Blagden SP, Berthold D, Cardin DB, Vieito M, Miller RE, Dass PH, Orcurto A, Spencer K, Janik JE, Clark J, Condamine T, Pulini J, Chen Xuejun, Mehnert JM. Journal for ImmunoTherapy of Cancer. 2022.
Inflammation & Neurology
Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses
Doan Ngoc TM, Tilly G, Danger R, Bonizec O, Masset C, Guérif P, Bruneau S, Glemain A, Harb J, Cadoux M, Vivet A, Le Mai H, Garcia A, Laplaud D, Liblau R, Giral M, Blandin S, Feyeux M, Dubreuil L, Pecqueur C, Cyr M, Ni W, Brouard S, Degauque N. Journal of the American Society of Nephrology. 2022.
Cancer Immunology
Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology
Amit M, Xie T, Gleber-Netto FO, Hunt PJ, Mehta GU, Bell D, Silverman DA, Yaman I, Ye Y, Burks JK, Fuller GN, Gidley PW, Nader ME, Raza SM, DeMonte F. Journal of Experimental & Clinical Cancer Research. 2022.
Cancer Immunology
Secreted Fas decoys enhance the antitumor activity of engineered and bystander T cells in Fas ligand–expressing solid tumors
Bajgain P, Torres Chavez AG, Balasubramanian K, Fleckenstein L, Lulla P, Heslop HE, Vera J, Leen AM. Cancer Immunology Research. 2022.
Cancer Immunology
Inhibition of integrin αVβ3 signaling improves the antineoplastic effect of bexarotene in cutaneous T-cell lymphoma
Cayrol F, Revuelta MV, Debernardi M, Paulazo A, Phillip JM, Zamponi N, Sterle HA, Díaz Flaqué MC, Magro CM, Marullo R, Mulvey E, Ruan J, Cremaschi GA, Cerchietti L. Molecular Cancer Therapeutics. 2022.