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Single-Cell Secretome and Functional Analysis of CAR Synapses

In a paper published in Nature Biotechnology, researchers used our Single-Cell Secretome solution to characterize CAR synapse formation for enhanced tumor cell killing and prolonged CAR NK cell survival in different tumor models.

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In this Paper Summary we discuss:

Anchoring CAR synapses.
Functional phenotyping for improved cell therapy.
CAR.PDZ affects cytokine secretion and NK cell function.
CAR synapse tuning and polyfunctionality.
A Deeper Look

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Improving Cell Therapy with Functional Phenotyping

Using Bruker Cellular Analysis’ IsoCode® Single-Cell Secretome platform and the IsoLight® system, Chockley and his colleagues demonstrated how modifying the CAR makeup can improve CAR NK efficacy, function, and anti-tumor activity.

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