Functional immune profiling with single-cell proteomics distinctively revealed the upregulation of polyfunctional monocytes with increasing severity of illness, providing novel insights for COVID-19 pathogenesis and progression.

This increase in polyfunctional inflammatory monocytes was likely suppressing T cell function in COVID-19 patients as disease severity increased, which points to a promising therapeutic target for COVID-19 treatment.

These unique insights help accelerate the comprehensive understanding of the immune response by providing potential biomarkers, which are crucial to identifying and developing effective therapeutics.

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