Identifying Elevated Neuroinflammatory Proteomic Markers in Cerebrospinal Fluid From COVID-19

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Paper Summary

In an article published in BMC Neurology, Shelli Farhadian and her Yale School of Medicine colleagues utilized our Functional Proteomics to research the case of a SARS-CoV-2 positive patient who initially presented with neurological rather than respiratory symptoms.

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Case presentation: neuroinflammation due to COVID-19

Functional proteomics reveals mechanisms in a new clinical presentation for COVID-19

Proteomic markers for neuroinflammation in COVID-19

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Measuring Inflammatory Cytokines in Both CSF and Plasma Samples with Functional Proteomics

The relationship between SARS-CoV-2 and the CNS is unclear, but CNS abnormalities appeared in both SARS and MERS cases from 2002-2004 and 2014, respectively.

Our highly-multiplexed cytokine assay used in this study is helping provide the necessary cellular-level data to reveal critical insights for mechanisms of neuroinflammation due to SARS-CoV-2 infection.

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