App Note
Gain Deeper Insights into Antibody Functionality Using High-Throughput Cell-Based Internalization Assays
Bruker’s advanced Beacon® optofluidic system enables efficient function-first screening of single antibody producing cells, leveraging live reporter cells to rapidly identify internalizing antibodies and accelerate antibody discovery and development.
What's Inside
In this App Note we discuss:
A function-focused antibody discovery campaign for internalizing antibodies targeting the programmed cell death ligand (PD-L1) using the Beacon optofluidic platform.
Back-to-back bead and live reporter cell–based assays enabling combinatorial profiling of thousands of single antibody-secreting cells to streamline early discovery of unique and functionally relevant antibody candidates.
Downstream re-expression and confirmation of unique functional antibody leads.