Employing PSI™ to Summarize Complex Single-cell Cytokine Data

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Tech Note

See how PSI correlates with the objective response across cancer immunotherapies and is accelerating discovery and development.

What's Inside

In this Tech Note we discuss:

Polyfunctionality alone is a meaningful indicator of potency in a variety of immunotherapy types, including CAR T therapy, where PSI has significantly outperformed other pre-infusion metrics

Many researchers are also using sub-components of the PSI to develop a sub-component polyfunctional strength cell subset driver, such as IL-17 or Stimulatory driven Polyfunctional Strength

The PSI Index reveals aggregate differences that guide your deep dive into polyfunctional cell subsets, via single-cell heat maps and cellular analyses like PAT PCA and t-SNE, that can reveal biomarkers and development insights

A Deeper Look

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Polyfunctional Strength Index (PSI)

PSI is a powerful, novel metric for measuring the potency of a variety of immune cell types in cancer immunotherapy, based on the ability to uniquely isolate & detect potent functional cell subsets.

PSI is generated by identifying the polyfunctional single cells (those cells secreting two or more cytokines) and measuring the intensity of the cytokines they secrete.

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