Characterizing T Cell Exhaustion and Hypofunctionality in Cancer

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Paper Summary

In a paper published in Science Translational Medicine, researchers outlined how they used our IsoCode® Single-Cell Secretome platform to study the CD8+ T cell landscape in glioblastoma (GBM).

What's Inside

In this Paper Summary we discuss:

Spanning the spectrum of T cell dysfunction.

Characterizing tolerized CD8+ T cell chemokines.

Uncovering the CD8+ T cell states behind ICB-non-responsive tumors.

A Deeper Look

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Paving the Road to Optimized Immunotherapies

This study provides a path forward for future research of immunotherapies targeting low-immunogenicity cancers, including non-responsive tumors such as GBM.

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