High-throughput screening (HTS) and DNA-encoded library (DEL) screening have each transformed early small molecule drug discovery, but historically, they’ve operated in parallel rather than in concert. Traditional DEL screening excels at identifying binders, while phenotypic HTS is relied upon to determine function. Bridging those two worlds with confidence and at scale has remained a persistent […]
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Perfusion: The Beating Heart of Single-Cell Biology and Cancer Immunotherapy
Single-cell biology has transformed our ability to uncover cellular diversity and dynamic behavior within complex tissues that are otherwise masked in population-level analyses. Yet, the precision of single-cell data critically depends on how cells are maintained and stimulated during experiments. In static cultures, nutrient depletion and waste accumulation occur rapidly, altering cellular metabolism and gene […]
Breaking New Ground in Functional Single-Cell Analysis: Meet the 2025 Beacon Discovery Grant Recipients
We recently announced the winners of our 2025 Beacon Discoveryâ„¢ Global Grant Program. These selected researchers stood out for their innovative use of single-cell functional analysis to tackle complex biological questions in immunology, oncology, and cell therapy. Each project showcases how the Beacon Discovery optofluidic platform can reveal previously inaccessible functional insights at the single-cell […]
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