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1 - 25 of 173 Publications
Cell Line Development
SiMPl-GS: Advancing Cell Line Development via Synthetic Selection Marker for Next-Generation Biopharmaceutical Production
Yoon C, Lee E, Kim D, Joung S, Kim Y, Jung H, Kim YG, Lee GM. Advanced Science. 2024.
Cellular and Regenerative Medicine
CD28 Costimulation Augments CAR Signaling in NK Cells via the LCK/CD3ζ/ZAP70 Signaling Axis
Acharya S, Basar R, Daher M, Rafei H, Li P, Uprety N, Ensley E, Shanley M, Kumar B, Banerjee PP, Garcia LM, Lin P, Mohanty V, Kim KH, Jiang X, Pan Y, Li Y, Liu B, Nunez Cortes AK, Zhang C, Fathi M, Rezvan A, Montalvo MJ, Cha SL, Reyes-Silva F, Shrestha R, Guo X, Kundu K, Biederstädt A, Muniz-Feliciano L, Deyter GM, Kaplan M, Jiang XR, Liu E, Jain A, Roszik J, Fowlkes NW, Solis Soto LM, Raso MG, Khoury JD, Lin P, Vega F, Varadarajan N, Chen K, Marin D, Shpall EJ, Rezvani K. Cancer Discovery. 2024.
Antibody Discovery
Protocol for isolating antigen-specific monoclonal antibodies from immunized mice utilizing the Beacon platform
Fu M, Wang X, Tang S, Bai S, Ding L, Hu Y, Cao K, Yang T, Zhao C, Zhang X, Xu J. STAR Protocols. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Cell therapy using ex vivo reprogrammed macrophages enhances antitumor immune responses in melanoma
Noonepalle SKR, Gracia-Hernandez M, Aghdam N, Berrigan M, Coulibaly H, Li X, Zevallos-Delgado C, Pletcher A, Weselman B, Palmer E, Knox T, Sotomayor E, Chiappinelli KB, Wardrop D, Horvath A, Shook BA, Lee N, Dritschilo A, Fernandes R, Musunuri K, Shibata M, Villagra A. Journal of Experimental & Clinical Cancer Research. 2024.
Stem cells
Dipeptidyl peptidase-4 marks distinct subtypes of human adipose stromal/stem cells with diferent hepatocyte diferentiation and immunoregulatory properties
Zhang Y, Hua M, Ma X, Li W, Cao Y, Han X, Huang X, Zhang H. Stem Cell Research & Therapy. 2024.
Stem cells
IL1RAP-specifc T cell engager depletes acute myeloid leukemia stem cells
Zhang Y, Park M, Ghoda LY, Zhao D, Valerio M, Nafe E, Gonzalez A, Ly K, Parcutela B, Choi H, Gong X, Chen F, Harada K, Chen Z, Nguyen LXT, Pichiorri F, Chen J, Song J, Forman SJ, Amanam I, Zhang B, Jin J, Williams JC, Marcucci G. Journal of Hematology and Oncology. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Interleukin-21 engineering enhances NK cell activity against glioblastoma via CEBPD
Shanley M, Daher M, Dou J, Li S, Basar R, Rafei H, Dede M, Gumin J, Pantaleón García J, Nunez Cortes AK, He S, Jones CM, Acharya S, Fowlkes NW, Xiong D, Singh S, Shaim H, Hicks SC, Liu B, Jain A, Zaman MF, Miao Q, Li Y, Uprety N, Liu E, Muniz-Feliciano L, Deyter GM, Mohanty V, Zhang P, Evans SE, Shpall EJ, Lang FF, Chen K, Rezvani K. Cancer Cell. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Targeting GPC2 on Intraocular and CNS Metastatic Retinoblastomas with Local and Systemic Delivery of CAR T Cells
Pascual-Pasto G, McIntyre B, Giudice AM, Alikarami F, Morrissey A, Matlaga S, Hofmann TJ, Burgueño V, Harvey K, Martinez D, Shah AC, Foster JB, Pogoriler J, Eagle RC, Carcaboso AM, Shields CL, Leahey AM, Bosse KR. Clinical Cancer Research. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma
Pascual-Pasto G, McIntyre B, Hines MG, Giudice AM, Garcia-Gerique L, Hoffmann J, Mishra P, Matlaga S, Lombardi S, Shraim R, Schürch PM, Yarmarkovich M, Hofmann TJ, Alikarami F, Martinez D, Tsang M, Gil-de-Gómez L, Spear TT, Bernt KM, Wolpaw AJ, Dimitrov DS, Li W, Bosse KR. Nature Communications. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Analysis of polyfunctionality for enhanced BAFF-R CAR T-cell therapy for hematologic malignancies
Dong Z, Budde LE, Oh E, Szymura S, Anderson A, Del Real M, Cha S, Forman SJ, Kwak LW, Wang X. Blood Advances. 2024.
Immunology
Stimulation-induced cytokine polyfunctionality as a dynamic concept
Portmann K, Linder A, Eyer K. eLife. 2024.
Oncology
Epigenetic Induction of Cancer-Testis Antigens and Endogenous Retroviruses at Single-Cell Level Enhances Immune Recognition and Response in Glioma
Lai TJ, Sun L, Li K, Prins TJ, Treger J, Li T, Sun MZ, Nathanson DA, Liau LM, Lai A, Prins RM, Everson RG. Cancer Research Communications. 2024.
Immunology
Generation of nanobodies from transgenic ‘LamaMice’ lacking an endogenous immunoglobulin repertoire
Eden T, Schaffrath AZ, Wesolowski J, Stähler T, Tode N, Richter N, Schäfer W, Hambach J, Hermans-Borgmeyer I, Woens J, Le Gall CM, Wendler S, Linke-Winnebeck C, Stobbe M, Budnicki I, Wanney A, Heitz Y, Schimmelpfennig L, Schweitzer L, Zimmer D, Stahl E, Seyfried F, Gebhardt AJ, Dieckow L, Riecken K, Fehse B, Bannas P, Magnus T, Verdoes M, Figdor CG, Hartlepp KF, Schleer H, Füner J, Tomas NM, Haag F, Rissiek B, Mann AM, Menzel S, Koch-Nolte F. Nature Communications. 2024.
Vaccines & Infectious Disease
Novel Bacteroides Vulgatus strain protects against gluteninduced break of human celiac gut epithelial homeostasis: a pre-clinical proof-of-concept study
Tran T, Senger S, Baldassarre M, Brosnan RA, Cristofori F, Crocco M, De Santis S, Elli L, Faherty CS, Francavilla R, Goodchild-Michelman I, Kenyon VA, Leonard MM, Lima RS, Malerba F, Montuori M, Morelli A, Norsa L, Passaro T, Piemontese P, Reed JC, Sansotta N, Valitutti F, Zomorrodi AR, Fasano A. Pediatric Research. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition
Andreu-Saumell I, Rodriguez-Garcia A, Mühlgrabner V, Gimenez-Alejandre M, Marzal B, Castellsagué J, Brasó-Maristany F, Calderon H, Angelats L, Colell S, Nuding M, Soria-Castellano M, Barbao P, Prat A, Urbano-Ispizua A, Huppa JB, Guedan S. Nature Communications. 2024.
Cancer Immunology
CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4
Chen S, Fan J, Xie P, Ahn J, Fernandez M, Billingham LK, Miska J, Wu JD, Wainwright DA, Fang D, Sosman JA, Wan Y, Zhang Y, Chandel NS, Zhang B. JCI. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
Marin D, Li Y, Basar R, Rafei H, Daher M, Dou J, Mohanty V, Dede M, Nieto Y, Uprety N, Acharya S, Liu E, Wilson J, Banerjee P, Macapinlac HA, Ganesh C, Thall PF, Bassett R, Ammari M, Rao S, Cao K, Shanley M, Kaplan M, Hosing C, Kebriaei P, Nastoupil LJ, Flowers CR, Moseley SM, Lin P, Ang S, Popat UR, Qazilbash MH, Champlin RE, Chen K, Shpall EJ, Rezvani K. Nature Medicine. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Immune-mediated facial nerve paralysis in a myeloma patient post B-cell maturation antigen-targeted chimeric antigen receptor T cells
Kathari YK, Ahmad H, Kallen ME, Koka R, Omili D, Iraguha T, Clement J, Pham L, Khalid M, Fan X, Gebru E, Lesho P, Park E, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Badros A, Yared JA, Dahiya S, Hardy NM, Kocoglu H, Luetkens T, Rapoport AP, Atanackovic D. Haematologica. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
Treatment of secondary CNS lymphoma using CD19‑targeted chimeric antigen receptor (CAR) T cells
Kline K, Luetkens T, Koka R, Kallen ME, Chen W, Ahmad H, Omili D, Iraguha T, Gebru E, Fan X, Miller A, Dishanthan N, Baker JM, Dietze KA, Hankey KG, Yared JA, Hardy NM, Rapoport AP, Dahiya S, Atanackovic D. Cancer Immunology, Immunotherapy. 2024.
Oncology
Differential Regulation of the STING Pathway in Human Papillomavirus–Positive and -Negative Head and Neck Cancers
Saulters EL, Kennedy PT, Carter RJ, Alsufyani A, Jones TM, Woolley JF, Dahal LN. Cancer Research Communications. 2024.
Oncology
Inorganic Nanoparticles Change Cancer-Cell-Derived Extracellular Vesicle Secretion Levels and Cargo Composition, Resulting in Secondary Biological Effects
Buttiens K, Maksoudian C, Perez Gilabert I, Rios Luci C, Manshian BB, Soenen SJ. ACS Applied Materials & Interfaces. 2024.
Cancer Immunology, Cellular and Regenerative Medicine
IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity
Landoni E, Woodcock MG, Barragan G, Casirati G, Cinella V, Stucchi S, Flick LM, Withers TA, Hudson H, Casorati G, Dellabona P, Genovese P, Savoldo B, Metelitsa LS, Dotti G. Nature Communications. 2024; doi: 10.1038/s41467-023-44310-y.
Antibody Discovery
Transcobalamin receptor antibodies in autoimmune vitamin B12 central deficiency
Pluvinage JV, Ngo T, Fouassier C, McDonagh M, Holmes BB, Bartley CM, Kondapavulur S, Hurabielle C, Bodansky A, Pai V, Hinman S, Aslanpour A, Alvarenga BD, Zorn KC, Zamecnik C, McCann A, Asencor AI, Huynh T, Browne W, Tubati A, Haney MS, Douglas VC, Louine M, Cree BAC, Hauser SL, Seeley W, Baranzini SE, Wells JA, Spudich S, Farhadian S, Ramachandran PS, Gillum L, Hales CM, Zikherman J, Anderson MS, Yazdany J, Smith B, Nath A, Suh G, Flanagan EP, Green AJ, Green R, Gelfand JM, DeRisi JL, Pleasure SJ, Wilson MR. Science Translational Medicine. 2024.
Antibody Discovery
Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5
Lawrence TW, Cooper A J.R., Farrell B, Draper S, Higgins MK. Cell. 2024.
Cell Line Development
Combined approach of selective and accelerated cloning for microfluidic chip-based system increases clone specific productivity
Desmurget C, Frentzel J, Strembitska A, Sobkowiak K, Perilleux A, Souquet J, Borth N, Douet J. Biotechnology Journal. 2024.